|Affiliation|| Nicholas Andre|
|Age||Late 30s to early 40s|
|First Appearance||Dumb and Dumber|
|Portrayed by||Mike Starr|
Joe Mentalino was a criminal who worked for Nicholas Andre, and the secondary antagonist of the 1994 film Dumb and Dumber. He suffered from digestive problems.
He is portrayed by Mike Starr.
In 1994, Joe was tasked with eliminating Lloyd Christmas and Harry Dunne. He posed as a hitchhiker and traveled with them for a while. At a diner, he planned to spike Harry and Lloyd rat poison to have control of the briefcase containing ransom money. He later changes his mind on killing them when he learns that they do not know what is in the briefcase, or the woman it belongs to, and eats lunch with them. Not knowing about Joe's condition, Lloyd and Harry retaliate for a previous prank, by filling his burger with atomic peppers bringing on some sort of allergic reaction, and he collapses holding onto his stomach, and requests his pills for his ulcer. Harry, who found the rat poison pills in Joe's jacket pocket, believed it to be the medicine, and gave it to Joe, who had barely seconds to realize what he was given by Harry. With his last breath and last words, he blames Harry for it and calls him an "SOB" and then gurgles and collapses down dead.
Joe was a cold-hearted killer and would murder without hesitation. This was shown when he decapitated Petey. He also had a bad temper, and punched a man who was annoying him straight through a phone box. His impatience was especially displayed when he was travelling with Harry and Lloyd, who irritated him with their stupidity.